Douwe M. T. Bosma

The paper shows that Th1 and Tfh cells originate from a common precursor and differentiate based on interactions with cDC1s or B cells.

This study shows that PD-1+TCF-1+ stem-like CD8+ T cells require CD4+ T-cell help to differentiate into effector cytotoxic T cells, but tumors fail to provide this help despite expressing helper epitopes.

This paper develops BCMA CAR T cells with a granzyme B-NOXA fusion to enhance apoptosis in multiple myeloma cells, improving killing efficacy in vitro and in xenograft models.