Lauren K. Yum

This study identifies ZitB as a bacterial factor that enhances Shigella flexneri fitness during macrophage-associated metal stress by mitigating metal toxicity.

This study uses microscopy and transcriptomics to analyze the sequential invasion of Shigella flexneri in colonic tissue, identifying two infection stages and bacterial association with immune cells in the late stage.

The paper uses scRNA-seq to show that monocyte IL1B expression inversely correlates with HIV-1 reservoir size in ART-treated individuals.

This study identifies PIK3C3 as essential for Shigella flexneri cell-to-cell spread by facilitating vacuole formation through PtdIns(3)P accumulation and Dynamin 2 recruitment.

The paper identifies a monocyte-derived transcriptome signature linked to antibody-dependent cellular phagocytosis as a correlate of vaccine-induced protection against HIV-1 in clinical trials.