Johannes Stigler

This study investigates how intra-protein interfaces influence folding dynamics and mechanical stability in a designed repeat protein using single-molecule techniques and simulations.

The paper identifies DDK-mediated phosphorylation of INO80's Arp8 subunit, which stabilizes the complex and regulates nucleosome spacing at replication origins, enhancing replication efficiency and stress response.

This study uses single-molecule imaging to show INO80 chromatin remodeler recognizes DNA shape features and interacts with nucleosomes and barrier factors to position them accurately.

This study uses single-molecule imaging to show CTCF's zinc fingers mediate clustering and RNA recruitment, enhancing cohesin stability at TAD borders.