Author

David Giesbrecht

Brown UniversityORCID 0000-0003-2498-4705Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Genetic & Genomic Medicine· 2 Genomics· 2

Signature Assays, Organisms & Methods

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Research Focus:variant calling· 4 Organism:plant (other)· 3 Approach:statistical model· 3 Assay:whole-genome sequencing· 3 Approach:experimental assay· 2 Research Focus:clustering· 1 Assay:DNA methylation· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

Jeffrey A. BaileyiD· 4 shared Jonathan J. JulianoiD· 3 shared Isaac E. KimiD· 2 shared Rebecca CrudaleiD· 2 shared Sin Ting HuiiD· 2 shared Aaron C. ErmeliD· 1 shared Abebe Alemu FolaiD· 1 shared Ann Marie MoormanniD· 1 shared

Activity by Year

2022-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

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4 shared papersGenetic & Genomic Medicine

Jeffrey A. BaileyORCID

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4 papers

Recent·Most cited

Genetic & Genomic MedicineScientific ReportsPeer-reviewedOct 7, 2025

Scalable long-read Nanopore HPV16 Amplicon-based Whole-Genome Sequencing

Titus Kipkemboi Maina, David Giesbrecht, Cliff I. Oduor…·Jeffrey A. Bailey

This paper develops a scalable long-read sequencing method for HPV16 genome analysis, showing high accuracy and capturing full genetic diversity across multiple lineages.

DOI 10.1038/s41598-025-18664-w

humanlong-read sequencing

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GenomicseLifePeer-reviewedOct 7, 2024

Interchromosomal segmental duplication drives translocation and loss of P. falciparum histidine-rich protein 3

Nicholas J. Hathaway, Isaac E. Kim, Neeva WernsmanYoung…·Jeffrey A. Bailey

The paper analyzes whole-genome-sequenced Plasmodium falciparum samples to understand gene deletions associated with malaria rapid diagnostic tests, identifying patterns of chromosomal rearrangements and duplication.

3 citations

plant (other)whole-genome sequencing

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Genetic & Genomic MedicinemedRxivPreprintJan 23, 2024

Genetic polymorphism and evidence of signatures of selection in the Plasmodium falciparum circumsporozoite protein gene in Tanzanian regions with different malaria endemicity

Beatus Modest Lyimo, Catherine Bakari, Zachary R. Popkin-Hall…·Deus S. Ishengoma

This study analyzes genetic diversity and selection signatures in the Pfcsp gene of Plasmodium falciparum from Tanzanian regions with varying malaria transmission to inform vaccine development.

1 citation

plant (other)whole-genome sequencing

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GenomicsbioRxivPreprintOct 26, 2022

Examining the early distribution of the artemisinin-resistant Plasmodium falciparum kelch13 R561H mutation in Rwanda

Rebecca Kirby, David Giesbrecht, Corine Karema…·Jean Baptiste Mazarati

The paper examines the early distribution of the Pfk13-R561H mutation in Rwanda using blood spot samples from a demographic health survey, finding spatial clustering of the mutation.

2 citations

plant (other)DNA methylation

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