Jessica I. Beynor

This study shows that combining immunotherapies can lead to divergent tumor responses based on the tumor microenvironment, with Treg depletion reversing progression in pancreatic cancer.

The paper identifies state-dependent eQTLs in memory T cells by analyzing single-cell RNA and protein data from Peruvians, showing that gene regulation varies with cell states and disease-associated variants are enriched in these contexts.

The paper identifies a common inflammatory macrophage phenotype across severe COVID-19 and other inflammatory diseases, driven by IFN-γ and TNF-α, and suggests potential therapeutic targets.