Tomáš Brabec

This study shows that Salmonella's flagellar T3SS translocates T3SS effectors into host cells, a process critical for infection and independent of the later-induced injectisome.

The study identifies Claudin 1 on DC1s as essential for their positioning near mTECs, facilitating antigen transfer and DC1 maturation, which maintains central tolerance.

This study shows that Jag1 deficiency in a mouse model of Alagille syndrome leads to impaired liver fibrosis due to defective T cell differentiation and hepatocyte maturation.