George Thom

This study identifies Artemis as a regulator of PRINS editing, showing that modulating Artemis improves insertion efficiency and specificity for genomic engineering.

STAMPS designs novel mammalian signal peptides to enhance protein secretion, outperforming existing benchmarks in multiple cell lines.

This paper improves prime editing by modulating DNA repair pathways and engineering pegRNA, achieving higher precision and efficiency in human and mouse cells.

This study demonstrates that systemic delivery of ASO conjugated to a brain-targeting antibody improves SMN2 splicing and survival in SMA mouse models.