Timothy D. Howard

This paper identifies 41 risk loci for juvenile idiopathic arthritis, including 14 novel ones, and presents a polygenic risk score associated with age of onset, along with functional mechanisms involving DNA topology and an HLA-A*02:01-ERAP2 interaction.

The paper develops a web-based tool to estimate sample sizes for non-human primate longitudinal studies using natural healthspan data.

This study examines how Western and Mediterranean diets affect monocyte gene expression and social behavior in macaques, finding proinflammatory gene changes and behavioral differences.

This study introduces DNA topology as a prioritization metric for genomic fine-mapping, using minor groove width changes to identify functionally relevant SNPs in non-coding regions associated with System Lupus Erythematosus.

The paper analyzes the proteomic architecture of human coronary and aortic atherosclerosis using mass spectrometry data from 200 specimens, identifying key protein networks and regulatory features associated with early disease.