Laura A. Cox

The paper identifies a molecular signature of age-related decline in vervet monkey skeletal muscle through multi-omics analysis, highlighting miRNA and epigenetic changes associated with sarcopenia.

The paper develops a web-based tool to estimate sample sizes for non-human primate longitudinal studies using natural healthspan data.

The paper develops and validates AI-based aging resilience biomarkers in non-human primates using longitudinal clinical data from baboons and rhesus macaques.

The paper identifies miRNA-gene regulatory networks associated with VO2peak in older adults using RNA sequencing and pathway analysis.

The paper identifies miRNA signatures associated with VO2peak variation in older adults using serum small RNA sequencing and statistical analysis.

The paper shows that targeted breeding strategies in rhesus macaques reduced SIV-refractory MHC haplotypes without decreasing genetic diversity.

This study computes sex-specific survival curves for 12 nonhuman primate species to characterize aging patterns and provides insights into lifespan and healthspan differences.

This study finds that aging baboons show sex-specific declines in prefrontal cortex mitochondrial bioenergetics, with males experiencing greater ETC activity loss and a link between walking speed and respiration in males.

This study identifies age-related metabolic shifts in baboon hearts that promote glycosaminoglycan accumulation via the hexosamine biosynthetic pathway, preceding cardiac hypertrophy.

This study examines the effects of maternal undernutrition on hepatic mitochondrial function in baboon offspring during aging, finding male-specific increases in mitochondrial bioenergetics without changes in plasma metabolites.

The paper identifies diet-responsive eQTLs in baboons exposed to high cholesterol and fat diets, showing their relevance to human metabolic GWAS genes.

The paper compares mitochondrial bioenergetics and cellular resilience across astrocytes, hepatocytes, and fibroblasts from aged baboons under different stressors.

The paper integrates multi-omics data from female baboons to identify age-related molecular changes in the prefrontal cortex, revealing altered signaling pathways and potential biomarkers for age-related cognitive decline.

This study integrates multi-omics data from female nonhuman primates to identify aging-related molecular changes in the liver, revealing age-associated pathways in endoplasmic stress and degradation.

This study uses genotype-by-sequencing on hair follicle DNA to genetically characterize a captive marmoset colony, revealing low inbreeding and identifying clinically significant SNVs.

This paper presents an open-source method to assess cell-type composition in bulk RNA-Seq data from heterogeneous tissues using scRNA-Seq references, showing no sex-based differences in kidney transcriptomes from baboons.

The paper investigates how high sodium diets affect kidney cortex transcriptomes and blood pressure in female nonhuman primates, identifying gene networks and regulators linked to BP response.

This study evaluates label-free quantification and missing value imputation methods in non-human primate proteomics to improve data quality and analysis.

This study estimates crossover and noncrossover recombination in olive baboons using whole-genome sequence data from pedigrees and compares results to LD-based estimates.

The paper integrates transcriptomics, proteomics, and metabolomics data from vervet monkeys to identify sirtuin signaling and PPARA network alterations in response to a high fructose diet.

The paper identifies five miRNAs associated with bone mineral density in healthy adult baboons, suggesting their role in normal aging and potential disease mechanisms.

This study shows that sulfonylureas reduce Alzheimer's pathology by targeting vascular KATP channels, decreasing amyloid-beta aggregation and improving vascular function in mice.

This paper presents a de novo genome assembly of the olive baboon using long-read and Hi-C data, significantly improving contig size and chromosome scaffolding compared to the previous reference genome.

This study examines how reduced maternal nutrition during pregnancy affects kidney function in nonhuman primates, showing persistent molecular and structural changes that influence responses to a high-fat, high-carbohydrate, high-salt diet.

The paper analyzes 100 high-coverage genomes from a captive baboon colony to catalog genetic variation, study ancestry, correct colony records, and investigate inbreeding effects.

A short-term Western diet exposure in baboons caused long-term metabolic changes, suggesting a reset of the metabolic program.