Author

Michael William Lutz

Duke UniversityORCID 0000-0001-8809-5574Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:statistical model· 4 Assay:bulk RNA-seq· 3 Research Focus:differential expression· 3 Organism:human· 3 Research Focus:gene regulatory network inference· 2 Organism:mouse· 2 Assay:proteomics· 2 Organism:rat· 2

Frequent Co-Authors

Alexandra BadeaiD· 2 shared Ali MahzarniaiD· 2 shared Alev M. BrigandeiD· 1 shared Allison ChangiD· 1 shared Allison E. Ashley‐KochiD· 1 shared Andrei Niculescu· 1 shared Andrew B. WestiD· 1 shared Anita A. DisneyiD· 1 shared

Activity by Year

2022-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 17 mutual co-author links

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2 shared papersGenetics

Alexandra BadeaORCID

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Author profile →

5 papers

Recent·Most cited

Integrated metabolomics and proteomics from voxelated cortical hemispheres of adult rhesus monkeys

Qiuyi Wu, Alev M. Brigande, Michael William Lutz, Pixu Shi, Anita A. Disney

The paper develops spatially registered metabolomics and proteomics maps of rhesus monkey cortex and integrates them using novel methods to identify conserved molecular gradients and metabolic circuits.

bioRxiv · Jul 13, 2026 · PreprintNeuroscience

A diagnostic plasma omics-biomarker for Alzheimer's disease informed by microglial single-cell transcriptomics: A pilot study

Michael William Lutz, Zhaohui Man, Yifei Zheng, Srilakshmi Venkatesan, Ornit Chiba‐Falek

The paper develops a blood-based diagnostic biomarker for Alzheimer's disease using microglial single-cell transcriptomics and validates it in plasma omics data.

Alzheimer s & Dementia Translational Research & Clinical Interventions · Apr 1, 2026Peer-reviewedGenomics

Single molecule array measures of LRRK2 kinase activity in serum link Parkinson's disease severity to peripheral inflammation

Yuan Yuan, Huizhong Li, Kashyap Sreeram, Tuyana B. Malankhanova, Ravindra Boddu, Samuel Strader, Allison Chang, Nicole Bryant, Talene A. Yacoubian, David G. Standaert, Madalynn L. Erb, Darren J. Moore, Laurie H. Sanders, Michael William Lutz, Dmitry Velmeshev, Andrew B. West

The paper measures LRRK2 kinase activity via pT73-Rab10 in serum, linking it to inflammation and Parkinson's disease severity.

Molecular Neurodegeneration · Jun 11, 2024Peer-reviewedNeuroscience

A Continuous Extension of Gene Set Enrichment Analysis using the Likelihood Ratio Test Statistics Identifies VEGF as a Candidate Pathway for Alzheimers disease

Ali Mahzarnia, Michael William Lutz, Alexandra Badea

The paper extends gene set enrichment analysis using likelihood ratio tests to identify VEGF as a pathway associated with Alzheimer's disease biomarkers and cognitive status.

bioRxiv · Aug 22, 2023 · PreprintGenetics

Genetic Substrates of Brain Vulnerability and Resilience in Aging APOE2 Mice

Ali Mahzarnia, Hae Sol Moon, Jacques Andrew Stout, Robert J. Anderson, Madison Strain, Jessica T. Tremblay, Zay Yar Han, Andrei Niculescu, Anna MacFarlane, Jasmine King, Allison E. Ashley‐Koch, Darin P. Clark, Michael William Lutz, Alexandra Badea

This study investigates how APOE2 alleles affect brain vulnerability and resilience in aging mice, identifying age-related brain atrophy, sex differences, and gene expression changes.

bioRxiv · Dec 12, 2022 · PreprintNeuroscience