Kai-Lieh Huang

This study shows CDK12 and CDK13 suppress distinct intronic polyadenylation sites, leading to premature termination and novel peptides in cancer.

This study identifies the UL26-PIAS1 complex as a mechanism by which HCMV inhibits anti-viral gene expression and promotes cell-to-cell spread.

The paper identifies inositol hexakisphosphate (IP6) as a critical regulator of Integrator assembly and function in Drosophila and humans.

The paper identifies an atlas of 3QTLs associated with alternative polyadenylation across 46 tissues, showing they explain 16.1% of trait-associated variants and contribute to disease independently of gene expression.

The paper shows the Integrator complex destabilizes paused RNA polymerase II at promoters, leading to termination of non-productive transcription.

The paper identifies the Integrator complex as a regulator of transcription by cleaving nascent mRNAs, revealing its role in attenuating gene expression during copper stress.

The paper identifies INTS4 as a conserved interaction partner of INTS9/11, forming a heterotrimeric complex critical for UsnRNA biogenesis.