Author

Liang Tong

Columbia UniversityORCID 0000-0002-0563-6468Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 7 Organism:human· 3 Organism:bacteria (other)· 2 Assay:multiome· 2 Research Focus:protein structure prediction· 2 Research Focus:cell type annotation· 1 Organism:Drosophila· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

Alexa Price‐WhelaniD· 2 shared Eric J. WagneriD· 2 shared Kai-Lieh HuangiD· 2 shared Lars E. P. DietrichiD· 2 shared Megerditch KiledjianiD· 2 shared Min-Han LiniD· 2 shared Yixuan WuiD· 2 shared Anthony W. DesotelliD· 1 shared

Activity by Year

2018-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 13 mutual co-author links

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2 shared papersMicrobiology

Alexa Price‐WhelanORCID

Mutual co-authors in cluster

Author profile →

7 papers

Recent·Most cited

Pseudomonas aeruginosa R-bodies deliver an ADP deaminase toxin

Devin T. King-Roberts, Kiavash Garakani, Thomas Tao, Hsin-Cheng Lin, Joshua Powell, Tongxin Wu, Eugenia Jin Lee, Tiffany M Yang, Mariia Serebriakova, Alexa Price‐Whelan, Virginia W. Cornish, Liang Tong, Lars E. P. Dietrich

This study identifies DeaR, an ADP deaminase toxin delivered by R-bodies of Pseudomonas aeruginosa, which alters purine metabolism and contributes to predation resistance.

bioRxiv · Oct 28, 2026 · PreprintMicrobiology

SUMO2 Promotes Histone Pre-mRNA Processing by Stabilizing Histone Locus Body Interactions and Facilitating U7 snRNP Assembly

Shuying He, Pin Lyu, Marnie W. Skinner, Anthony W. Desotell, Brendan Foley, Chance M McCaig, Wei Wang, Qian Jiang, Liang Tong, William F. Marzluff, Michael J. Matunis

This study shows SUMO2 stabilizes HLB interactions and facilitates U7 snRNP assembly, preventing histone mRNA polyadenylation.

Genes & Development · Jul 10, 2025Peer-reviewedMolecular Biology

The L-lactate dehydrogenases of Pseudomonas aeruginosa are conditionally regulated but both contribute to survival during macrophage infection

Lindsey C. Florek, Xi Lin, Yu‐Cheng Lin, Min-Han Lin, Arijit Chakraborty, Alexa Price‐Whelan, Liang Tong, Laurence G. Rahme, Lars E. P. Dietrich

This paper investigates the regulation and role of L-lactate dehydrogenases LldD and LldA in Pseudomonas aeruginosa, showing they are conditionally expressed and contribute to survival during macrophage infection.

mBio · Aug 20, 2024Peer-reviewedMicrobiology

Identification of a novel deFADding activity in 5' to 3' exoribonucleases

Sunny Sharma, Jun Yang, Selom K. Doamekpor, Ewa Grudizen-Nogalska, Liang Tong, Megerditch Kiledjian

The paper identifies deFADding activity in 5' to 3' exoribonucleases, showing they can degrade FAD-capped RNAs in yeast, human, and bacterial systems.

bioRxiv · May 10, 2022 · PreprintMolecular Biology

Inositol hexakisphosphate is a critical regulator of Integrator assembly and function

Min-Han Lin, Madeline K. Jensen, Nathan D. Elrod, Kai-Lieh Huang, Eric J. Wagner, Liang Tong

The paper identifies inositol hexakisphosphate (IP6) as a critical regulator of Integrator assembly and function in Drosophila and humans.

bioRxiv · Sep 14, 2021 · PreprintMolecular Biology

Structural and biochemical studies define Nudt12 as a new class of RNA deNADding enzyme in mammalian cells

Ewa Grudzien‐Nogalska, Yixuan Wu, Xinfu Jiao, Huijuan Cui, Ronald P. Hart, Liang Tong, Megerditch Kiledjian

This study identifies Nudt12 as a new deNADding enzyme distinct from DXO, showing it targets NAD-capped RNAs and links these RNAs to cellular metabolism.

bioRxiv · Nov 20, 2018 · PreprintMolecular Biology

Integrator Subunit 4 is a ‘Symplekin-like’ Scaffold that Associates with INTS9/11 to Form the Integrator Cleavage Module

Todd R. Albrecht, Sergey P. Shevtsov, Yixuan Wu, Lauren G. Mascibroda, Natoya J. Peart, Kai-Lieh Huang, Iain A. Sawyer, Liang Tong, Miroslav Dundr, Eric J. Wagner

The paper identifies INTS4 as a conserved interaction partner of INTS9/11, forming a heterotrimeric complex critical for UsnRNA biogenesis.

Nucleic Acids Research · Feb 17, 2018Peer-reviewedMolecular Biology