Darshan Sapkota

This study shows that 2,6-diaminopurine enhances Aqp4 stop codon readthrough and increases AQP4X levels in vivo.

The paper identifies cell-type and disease-specific circadian gene expression changes in glial cells under amyloid pathology or aging in mice.

The paper introduces a new microscopy technique to improve imaging of cardiac structures across multiple scales and stages.

This study evaluates the role of AQP4 readthrough isoforms in gliovascular functions using a novel mouse model and finds that AQP4x modulates BBB integrity and protein localization.

The paper uses single-cell RNA-seq to analyze retinal ganglion cell lineage development in wild-type and Atoh7-null retinas, revealing a transitional cell state and revised understanding of Atoh7's role.

The paper identifies Apigenin as a compound that enhances Aqp4 stop codon readthrough, potentially offering a therapeutic strategy for Alzheimer's disease.

The paper shows astrocytes have a translational response to neuronal activity, altering their proteome at synapses through BDNF and K+ signals.

This paper describes a mouse line with inducible Cre expression specifically targeting Remak Schwann cells, with partial neuronal depletion using Flpe.