Adelyn E. Ragucci

The paper identifies a bacterial anti-phage defense system called Panoptoo, which uses DAC enzymes to synthesize nucleotide signals that counteract phage immune evasion.

The paper analyzes 16 nuclease-NTPase systems to identify shared features controlling bacterial anti-phage defense, revealing universal protein complex formation and broad nucleic acid degradation capabilities.

This study identifies anti-defense proteins in phages that inhibit bacterial immune systems like Gabija, Thoeris, and Hachiman.