Adam V. Kwiatkowski

The paper shows that mechanical force opens the E-catenin M-region, enabling afadin condensate formation at high-load adherens junctions in cardiomyocytes.

The paper shows N-cadherin is orientationally ordered at low mechanical load cardiomyocyte junctions but disordered at high load, indicating adaptation to local force conditions.

The paper identifies the DSG2 interactome in neonatal cardiomyocytes, revealing shared and unique proteins involved in intercalated disc function.

The paper shows actomyosin forces cause desmoplakin to change conformation in desmosomes, revealing its mechanosensitivity.

This study shows that vinculin Y822 phosphorylation regulates cardiomyocyte adhesion dynamics and adherens junction maturation, with loss of function leading to cardiac dysfunction later in life.

The paper optimizes fluorogen-activating proteins (FAPs) for use in S. cerevisiae to enable quantitative endocytic studies and co-localization analysis of proteins.

The paper uses evolutionary rate covariation analysis to identify genes coevolving with Drosophila E-cadherin, revealing novel regulators of cell adhesion and actin dynamics.