Nicholas E. Clifton

The paper integrates multiomic data from human brain nuclei with GWAS statistics to prioritize neural cell types associated with brain-related traits.

The paper identifies neuron-specific DNA methylation differences in schizophrenia using cell type-resolved epigenome-wide association study in prefrontal cortex nuclei.

The paper identifies RNA-binding proteins (RBPs) whose regulation of synaptic mRNAs is enriched for schizophrenia genetic risk variants.

The paper examines the expression patterns of dystonia-causing genes across developmental stages and brain regions to identify key areas and cell types for disease modeling and therapy.

This study identifies cell-type-specific DNA methylation dynamics in the human cortex across development, highlighting prenatal periods as critical for epigenomic plasticity and linking changes to neurodevelopmental disorders.

This paper investigates how genetic liabilities shared and differentiating between schizophrenia and bipolar disorder relate to cognition and educational attainment using UK Biobank data.

This study shows that KDM5B deficiency in mice leads to autism-like behaviors and increased brain size, which can be mitigated by NMDAR antagonists.

The paper examines the developmental expression of genes related to voltage-gated cation channels and their association with psychiatric disorders, finding that gene expression patterns vary with age and disorder type.

The paper examines the genetic association of FMRP targets with schizophrenia, major depressive disorder, and bipolar disorder, finding enrichment for risk alleles and variants in these disorders.

The paper links reduced cortical morphometric similarity in psychosis to the expression of schizophrenia-related genes in specific brain regions.

The paper examines the dynamic expression of risk genes for schizophrenia and bipolar disorder across developmental stages in brain regions, finding distinct expression patterns between the two disorders.