Sónia Fonseca

Barcoded-Plasmid DNA library construction for recording cell lineage trees enabled by a Scalable and modular Biofoundry-based Automated Robotic Pipeline

The paper describes an automated robotic pipeline for high-throughput plasmid DNA purification and uses it to build a lentiviral DNA plasmid library for lineage tracing.

FlowFI: an interactive graphical software package for bespoke design of imaging parameters in flow cytometry to explore morphological diversity in bone marrow megakaryocytes

FlowFI is an open-source software tool for designing and refining imaging parameters in flow cytometry to improve the analysis of rare cell populations like bone marrow megakaryocytes.

Extracellular vesicles produced by the human commensal gut bacterium Bacteroides thetaiotaomicron affect host immune pathways in a cell-type specific manner that are altered in inflammatory bowel disease

This study shows that extracellular vesicles from Bacteroides thetaiotaomicron affect host immune pathways differently in various cell types and disease states, with implications for IBD therapy.

Regulation of blood-brain barrier integrity by microbiome-associated methylamines and cognition by trimethylamine N-oxide

This study shows that TMAO enhances BBB integrity and protects against inflammation, while TMA impairs BBB function and cognitive resilience in mice.