BiochemistrymBioPeer-reviewed
Antibiotic that inhibits trans-translation blocks binding of EF-Tu to tmRNA but not to tRNA
Neeraja Marathe, Ha An Nguyen, John N. Alumasa…·Kenneth C. Keiler
This paper identifies KKL-55, a tetrazole-based antibiotic that specifically inhibits EF-Tu binding to tmRNA without affecting tRNA binding, suggesting a new target for antibiotic development.