John N. Alumasa

This study identifies JNAL-042, an isoindole-benzohydrazide derivative that enhances colistin activity against MCR-1-resistant E. coli.

The paper determines the Cryo-EM structure of Cfr, revealing its mechanism of C8 methylation on 23S rRNA and its role in antibiotic resistance.

This study identifies an adjuvant, JNAL-016, that inhibits SaErmC-mediated resistance in E. coli, restoring antibiotic efficacy against macrolides and lincosamides.

This study identifies KKL-1005 as a trans-translation inhibitor that targets ribosomal protein bL12 in Mycobacterium tuberculosis, showing it specifically disrupts the trans-translation pathway.

This paper shows that trans-translation inhibitors KKL-40 and KKL-55 synergize with copper ions to enhance antibacterial activity against B. subtilis by causing rapid translation stalling and preventing copper toxicity response.