Maxence Noël

This study identifies disrupted O-GalNAc glycosylation as a mechanism and biomarker for SLC35A2-associated epilepsy using mouse models and human tissue analysis.

The paper investigates the N-glycome changes during neuronal differentiation and finds that brain-specific N-glycans like Man-5 are programmed independently of the transcriptome.

The paper identifies O-GalNAc glycans' spatial enrichment in white matter and their role in regulating nodes of Ranvier through glycoproteomic analysis and functional experiments.

The paper identifies distinct spatial distributions of N-glycans in the mouse brain using lectin-based staining.

This study shows that the schizophrenia-associated SLC39A8 variant A391T alters N-glycosylation in the mouse brain, affecting glycoproteins involved in schizophrenia-related pathways.

The paper analyzes glycosylation patterns in mouse brain regions and sexes, finding reduced complexity and minimal sex differences compared to plasma.