Richard D. Cummings

N-Glycopedia: Libraries for Native N-glycan Structural Analysis

The paper introduces N-glycopedia, a resource of N-glycan standards and analytical methods for structural analysis, enabling more accurate glycomics research.

Disrupted O-GalNAc glycosylation as a mechanism and biomarker of SLC35A2-associated epilepsy

This study identifies disrupted O-GalNAc glycosylation as a mechanism and biomarker for SLC35A2-associated epilepsy using mouse models and human tissue analysis.

Antibody-Fab and -Fc features promote Mycobacterium tuberculosis restriction.

This study identifies protective antibodies against Mycobacterium tuberculosis and shows that their Fc-effector function and Fab domains collaborate to restrict infection through immune cell reorganization.

A glycan atlas of the mammalian intestine through ontogeny and inflammation

This paper maps intestinal glycans across development, diet, and inflammation in mice and humans, identifying dynamic changes and microbiome influences.

The restricted N-glycome of neurons is programmed during differentiation

The paper investigates the N-glycome changes during neuronal differentiation and finds that brain-specific N-glycans like Man-5 are programmed independently of the transcriptome.

O-GalNAc glycans enrich in white matter tracts and regulate nodes of Ranvier

The paper identifies O-GalNAc glycans' spatial enrichment in white matter and their role in regulating nodes of Ranvier through glycoproteomic analysis and functional experiments.

N-glycans show distinct spatial distribution in mouse brain

The paper identifies distinct spatial distributions of N-glycans in the mouse brain using lectin-based staining.

The schizophrenia-associated variant in SLC39A8 alters N-glycosylation in the mouse brain

This study shows that the schizophrenia-associated SLC39A8 variant A391T alters N-glycosylation in the mouse brain, affecting glycoproteins involved in schizophrenia-related pathways.

The restricted nature of protein glycosylation in the mammalian brain

The paper analyzes glycosylation patterns in mouse brain regions and sexes, finding reduced complexity and minimal sex differences compared to plasma.