Edward M. Scolnick

This study identifies TAK-418 as a histone demethylase inhibitor that rescues schizophrenia-like phenotypes in Setd1a-deficient mice by restoring H3K4me3 levels and gene expression.

This study identifies somatic copy number variants (sCNVs) in schizophrenia cases, revealing their contribution to risk and specific NRXN1 disruptions.

This study shows that deleting GIT1 in the brain impairs cognition and disrupts phosphorylation networks of synaptic proteins linked to schizophrenia and neurodevelopmental disorders.

Exomes of 24,248 schizophrenia cases and 97,322 controls implicate ultra-rare damaging variants in 10 genes, including GRIN2A and GRIA3, with odds ratios of 3 to 50.

This study shows that the schizophrenia-associated SLC39A8 variant A391T alters N-glycosylation in the mouse brain, affecting glycoproteins involved in schizophrenia-related pathways.

The paper analyzes glycosylation patterns in mouse brain regions and sexes, finding reduced complexity and minimal sex differences compared to plasma.