Author

Laurinda A. Jaffe

UConn HealthORCID 0000-0003-2636-5721Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Developmental Biology· 4

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:mouse· 4 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Assay:imaging· 1 Research Focus:spatial domain detection· 1

Frequent Co-Authors

C. M. OweniD· 2 shared Deborah Kaback· 2 shared Giulia VigoneiD· 2 shared Jeremy R. Egbert· 2 shared Leia C. ShuhaibariD· 2 shared Siu‐Pok YeeiD· 2 shared Tracy F. Uliasz· 2 shared Caroline N. DealyiD· 1 shared

Activity by Year

2017-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 34 mutual co-author links

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2 shared papersDevelopmental Biology

C. M. OwenORCID

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4 papers

Recent·Most cited

Developmental BiologyEndocrinologyPeer-reviewedMay 26, 2026

Conditional replacement of the mouse LH receptor with GFP, enabling imaging of cell migration during ovulation

C. M. Owen, Katie M. Lowther, Deborah Kaback…·Siu‐Pok Yee

This paper describes a mouse line enabling conditional replacement of the LHR with GFP to study cell migration during ovulation.

1 citationtop 4%

𝕏 PostBluesky

Developmental BiologyBiology of ReproductionPeer-reviewedOct 13, 2023

Luteinizing hormone stimulates ingression of granulosa cells within the mouse preovulatory follicle.

C. M. Owen, Laurinda A. Jaffe

The paper shows LH induces granulosa cell ingression in the mural granulosa layer, contributing to structural changes during ovulation.

24 citationstop 3%

mouseexperimental assay

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Developmental BiologybioRxivPreprintSep 10, 2020

The phosphatase inhibitor LB-100 acts synergistically with the NPR2 agonist BMN-111 to improve bone growth

Leia C. Shuhaibar, Nabil Kaci, Jeremy R. Egbert…·Laurence Legeai‐Mallet

The paper shows that combining the phosphatase inhibitor LB-100 with the NPR2 agonist BMN-111 enhances bone growth in a mouse model of achondroplasia.

1 citation

mouseexperimental assay

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Developmental BiologyeLifePeer-reviewedDec 4, 2017

Dephosphorylation of the NPR2 guanylyl cyclase contributes to inhibition of bone growth by fibroblast growth factor

Leia C. Shuhaibar, Jerid W. Robinson, Giulia Vigone…·Laurinda A. Jaffe

The paper shows that dephosphorylation of NPR2 reduces cyclic GMP, counteracting bone elongation induced by FGF signaling.

34 citations

mouseexperimental assay

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