The phosphatase inhibitor LB-100 acts synergistically with the NPR2 agonist BMN-111 to improve bone growth
Leia C. Shuhaibar, Nabil Kaci, Jeremy R. Egbert, Léa Loisay, Giulia Vigone, Tracy F. Uliasz, Emilie Dambroise, Mark R. Swingle, Richard E. Honkanen, Laurinda A. Jaffe, Laurence Legeai‐Mallet
The paper shows that combining the phosphatase inhibitor LB-100 with the NPR2 agonist BMN-111 enhances bone growth in a mouse model of achondroplasia.
bioRxiv · Sep 10, 2020 · PreprintDevelopmental Biology