Dephosphorylation of the NPR2 guanylyl cyclase contributes to inhibition of bone growth by fibroblast growth factor
Leia C. Shuhaibar, Jerid W. Robinson, Giulia Vigone, Ninna Shuhaibar, Jeremy R. Egbert, Valentina Baena, Tracy F. Uliasz, Deborah Kaback, Siu‐Pok Yee, Robert Feil, Melanie C. Fisher, Caroline N. Dealy, Lincoln Ross Potter, Laurinda A. Jaffe
The paper shows that dephosphorylation of NPR2 reduces cyclic GMP, counteracting bone elongation induced by FGF signaling.
eLife · Dec 4, 2017Peer-reviewedDevelopmental Biology