Author

J. Rafael Ciges-Tomas

University of CopenhagenORCID 0000-0003-2647-3052Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 1

Signature Assays, Organisms & Methods

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Research Focus:cell signaling & trafficking· 1 Assay:cryo-EM· 1 Approach:experimental assay· 1

Frequent Co-Authors

Carmen G. LechugaiD· 1 shared Eduardo ZarzuelaiD· 1 shared Gonzalo AizpuruaiD· 1 shared Guillermo MontoyaiD· 1 shared Jesper.V. OlseniD· 1 shared Laura de la Puente OvejeroiD· 1 shared Leander van der HoeveniD· 1 shared Lucia Lomba-RiegoiD· 1 shared

Activity by Year

2026-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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1 shared paperBiochemistry

Carmen G. LechugaORCID

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1 paper

Recent·Most cited

BiochemistrybioRxivPreprintMar 27, 2026

The HSP90-CDC37 Chaperone System Orchestrates RAF1 Kinase Activation Through a Pre-Dimerization Mechanism

Gonzalo Aizpurua, Pablo Mesa, Laura de la Puente Ovejero…·Guillermo Montoya

This study reveals the HSP90-CDC37 chaperone system's role in RAF1 activation through pre-dimerization and asymmetric folding, showing its active regulatory role in MEK signaling and cell proliferation.

3 citations

cryo-EMexperimental assay

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