Author

Gonzalo Aizpurua

Spanish National Cancer Research CentreORCID 0000-0002-4572-2272Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 1 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell signaling & trafficking· 2 Approach:experimental assay· 2 Research Focus:cancer & tumor microenvironment· 1 Assay:cryo-EM· 1 Research Focus:drug response / drug discovery· 1 Approach:genetic perturbation / CRISPR· 1 Organism:mouse· 1 Assay:proteomics· 1

Frequent Co-Authors

Laura de la Puente OvejeroiD· 2 shared Lucia Lomba-RiegoiD· 2 shared Mariano BarbacidiD· 2 shared Sara García‐AlonsoiD· 2 shared Ana DomosteguiiD· 1 shared Carmen G. LechugaiD· 1 shared Cristina Mayor‐RuiziD· 1 shared Eduardo ZarzuelaiD· 1 shared

Activity by Year

2026-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 36 mutual co-author links

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2 shared papersCancer Biology

Laura de la Puente OvejeroORCID

Mutual co-authors in cluster

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2 papers

Recent·Most cited

RAF1 scaffold integrity shapes chemogenetic degradation outcomes in KRAS-driven lung cancer

Laura de la Puente Ovejero, Ana Domostegui, Inés María García-Pérez, Gonzalo Aizpurua, Lucia Lomba-Riego, Pilar Ximénez‐Embún, Cristina Mayor‐Ruiz, Mariano Barbacid, Sara García‐Alonso

This study shows that chemogenetic degradation of RAF1 in KRAS-driven lung cancer does not replicate genetic ablation outcomes due to scaffold disruption.

bioRxiv · Jul 6, 2026 · PreprintCancer Biology

The HSP90-CDC37 Chaperone System Orchestrates RAF1 Kinase Activation Through a Pre-Dimerization Mechanism

Gonzalo Aizpurua, Pablo Mesa, Laura de la Puente Ovejero, J. Rafael Ciges-Tomas, Lucia Lomba-Riego, Carmen G. Lechuga, Eduardo Zarzuela, Marta Isasa, Leander van der Hoeven, Jesper.V. Olsen, Mariano Barbacid, Sara García‐Alonso, Guillermo Montoya

This study reveals the HSP90-CDC37 chaperone system's role in RAF1 activation through pre-dimerization and asymmetric folding, showing its active regulatory role in MEK signaling and cell proliferation.

bioRxiv · Mar 27, 2026 · PreprintBiochemistry