Laura de la Puente Ovejero

RAF1 scaffold integrity shapes chemogenetic degradation outcomes in KRAS-driven lung cancer

This study shows that chemogenetic degradation of RAF1 in KRAS-driven lung cancer does not replicate genetic ablation outcomes due to scaffold disruption.

The HSP90-CDC37 Chaperone System Orchestrates RAF1 Kinase Activation Through a Pre-Dimerization Mechanism

This study reveals the HSP90-CDC37 chaperone system's role in RAF1 activation through pre-dimerization and asymmetric folding, showing its active regulatory role in MEK signaling and cell proliferation.

Duchenne Muscular Dystrophy Cell Culture Models Created By CRISPR/Cas9 Gene Editing And Their Application To Drug Screening

The paper describes CRISPR/Cas9-generated Duchenne muscular dystrophy cell models for drug screening, showing successful exon deletion and utrophin upregulation.