Ming Chen Hammond

This paper develops a nuclease-stable L-RNA glycine sensor using cross-chiral ligation, enabling extracellular glycine detection in serum.

The paper develops FRET-based c-di-GMP biosensors and applies them with FRET-To-Sort to map regulatory networks controlling c-di-GMP levels in E. coli.

The paper develops a fluorescence-based assay to screen and optimize substrate channeling in enzymatic cascades, identifying a linker variant that enhances product yield and current output in bioelectrocatalysis.

The paper develops a dual RNA biosensor to detect c-di-GMP and cGAMP in live bacteria, revealing regulatory mechanisms of CDN synthesis.

The paper develops a conditional degron system in bacteria that stabilizes fluorescent proteins and enzymes in the presence of TAR RNA, demonstrating a biosensor that integrates protein and RNA components from a single transcript.

This paper develops a ratiometric bioluminescent biosensor to image cyclic di-GMP levels in bacteria during host infection.