Human iPSC-Based Model Reveals NOX4 as Therapeutic Target in Duchenne Cardiomyopathy
Robin Duelen, Domiziana Costamagna, Guillaume Gilbert, Liesbeth De Waele, Nathalie Goemans, Kaat Desloovere, Catherine M. Verfaillie, Karin R. Sipido, Gunnar Buyse, Maurilio Sampaolesi
This study uses DMD patient iPSCs to model cardiomyopathy, identifies NOX4 as a therapeutic target due to its role in ROS production, and shows interventions that reduce oxidative stress and improve cell survival.
Stem Cell Reports · Jan 27, 2022Peer-reviewedDevelopmental Biology