Maurilio Sampaolesi

Pde5a Deficiency Prevents Diet-Induced Obesity via Adipose cAMP-PKA Activation Enhancing Fat Browning

This study shows that Pde5a deficiency prevents diet-induced obesity by enhancing adipose cAMP-PKA activation, leading to fat browning and improved metabolic outcomes.

Adult stem cell characterization from the Medial Gastrocnemius and Semitendinosus muscles in early development of cerebral palsy pathology

This study examines adult stem cell fusion capacity in CP patients, finding higher fusion in Medial Gastrocnemius muscle compared to typically developing children, with reduced potency in Semitendinosus muscle.

PGC-1α in the myofibers regulates the balance between myogenic and adipogenic progenitors affecting muscle regeneration

This study shows that PGC-1α in myofibers increases myogenic progenitors and reduces adipogenesis, enhancing muscle regeneration.

Human iPSC-Based Model Reveals NOX4 as Therapeutic Target in Duchenne Cardiomyopathy

This study uses DMD patient iPSCs to model cardiomyopathy, identifies NOX4 as a therapeutic target due to its role in ROS production, and shows interventions that reduce oxidative stress and improve cell survival.

Cardiomyocyte differentiation from iPS cells is delayed following knockout of Bcl-2

This study shows that Bcl-2 knockout in hiPSCs delays cardiomyocyte differentiation and reduces c-Myc expression, but not functionality in active areas.

Human motor units in microfluidic devices are impaired by FUS mutations and improved by HDAC6 inhibition

This study uses a microfluidic model of human motor units to show that FUS mutations impair neurite outgrowth and NMJ formation, which can be mitigated by HDAC6 inhibition.

Autologous micrograft accelerates endogenous wound healing response via ERK-induced cell migration

This study shows that autologous micrograft therapy accelerates wound healing by enhancing fibroblast migration through ERK pathway activation and increased matrix metalloproteinase activity.