Author
Montreal Neurological Institute and HospitalORCID 0000-0003-2711-3833Unclaimed ORCID profile · follow to get notified of new preprints
3 papers
Recent·Most cited
Peter Kunach, Jaime Vaquer‐Alicea, Matthew S. Smith…·Sarah H. Shahmoradian
The paper determines the cryo-EM structure of Alzheimer's disease tau filaments bound by the PET ligand MK-6240, revealing key binding interactions that inform ligand design.
Lazaro M. Sanchez-Rodriguez, Ahmed Faraz Khan, Quadri Adewale…·Yasser Iturria‐Medina
The paper uses computational models to identify transcriptomic signatures linked to Aβ and tau-induced neuronal dysfunction in Alzheimer's disease, highlighting immune and inflammatory processes.
Lazaro M. Sanchez-Rodriguez, Gleb Bezgin, Félix Carbonell…·Yasser Iturria‐Medina
The paper develops a personalized brain activity model integrating functional MRI, Aβ, and tau-PET to reveal synergistic effects of Aβ and tau on cognitive impairment and neuronal excitability in Alzheimer's disease.