Author

Jon M. Madison

Broad InstituteORCID 0000-0003-2728-7497Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Neuroscience· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Organism:human· 1 Organism:mouse· 1 Approach:statistical model· 1

Frequent Co-Authors

Aarno V. PalotieiD· 1 shared Adam Skepner· 1 shared Aditi Trehan· 1 shared Alex Guletsky· 1 shared Alexander A. LobodaiD· 1 shared Amanda Beccard· 1 shared Andrea GannaiD· 1 shared Anna K. KähleriD· 1 shared

Activity by Year

2022-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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1 shared paperNeuroscience

Aarno V. PalotieORCID

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2 papers

Recent·Most cited

Pharmacology & ToxicologyACS Chemical NeurosciencePeer-reviewedOct 29, 2026

Discovery of GluA3 preferring AMPA receptor positive allosteric modulator BRD3290

Christopher Greaves, William E. Martenis, Shawn Dwayne Nelson…·Sean P. Moran

This study discovers BRD3290, a GluA3-preferring AMPA receptor PAM, but finds it does not improve cognitive function in mice despite target engagement.

DOI 10.1021/acschemneuro.6c00573

mouseexperimental assay

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NeuroscienceNature CommunicationsPeer-reviewedJun 27, 2022

The 22q11.2 region regulates presynaptic gene-products linked to schizophrenia

Ralda Nehme, Olli P. H. Pietiläinen, Mykyta Artomov…·Kevin C. Eggan

This study investigates how the 22q11.2 deletion affects gene expression in neural progenitor cells and neurons, linking it to schizophrenia risk through altered presynaptic gene products.

58 citationstop 2%

humanbulk RNA-seq

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