Author

Adam Skepner

Broad Institute

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioinformatics· 1 Cancer Biology· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 3 Approach:deep learning· 2 Approach:experimental assay· 2 Organism:human· 1 Organism:mouse· 1 Assay:protein structure· 1 Assay:proteomics· 1 Approach:wet-lab / biochemical assay· 1

Frequent Co-Authors

Wei JiangiD· 2 shared Adam S. Sperling· 1 shared Alex Guletsky· 1 shared Alexandra E. GouldiD· 1 shared Arthur J. CampbelliD· 1 shared Bai ZheniD· 1 shared Cameron Schluter· 1 shared Carol Khodier· 1 shared

Activity by Year

2024-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 19 mutual co-author links

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2 shared papersBioinformatics

Wei JiangORCID

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Author profile →

3 papers

Recent·Most cited

Discovery of GluA3 preferring AMPA receptor positive allosteric modulator BRD3290

Christopher Greaves, William E. Martenis, Shawn Dwayne Nelson, Jon M. Madison, Adam Skepner, David Báez-Nieto, Katherine J. Stalnaker, Evan P. Lebois, Arthur J. Campbell, Katie Pelham, Mihaela Magdei, Alex Guletsky, Karen Perez de Arce, Yanling Zhang, Florence F. Wagner, , Sean P. Moran

This study discovers BRD3290, a GluA3-preferring AMPA receptor PAM, but finds it does not improve cognitive function in mice despite target engagement.

ACS Chemical Neuroscience · Oct 29, 2026Peer-reviewedPharmacology & Toxicology

ExplainBind: Explainable Physicochemical Determinants of Protein-Ligand Binding via Non-Covalent Interactions

Zhaohan Meng, Bai Zhen, Ke Yuan, Jiangning Song, Yumeng Zhang, Jaime H. Cheah, Wei Jiang, Adam Skepner, Kevin J. Leahy, Iadh Ounis, William M. Oldham, Zaiqiao Meng, Hao Xu, Joseph Loscalzo

ExplainBind predicts protein-ligand binding likelihood and identifies key residues and non-covalent interactions without structural inputs, outperforming existing methods and enabling drug discovery insights.

bioRxiv · Jun 9, 2026 · PreprintBioinformatics

Identification of Small Molecule Inhibitors of PPM1D Using a Novel Drug Discovery Platform

Wei Jiang, Subrata Shaw, Jason Rush, Nancy Dumont, John Kim, Ritu Singh, Adam Skepner, Carol Khodier, Cerise Raffier, Ni Yan, Cameron Schluter, Xiao Yu, Mateusz Szuchnicki, Murugappan Sathappa, Josephine Kahn, , Peter G. Miller

This study identifies new PPM1D inhibitors using a drug discovery platform and shows their distinct biological effects compared to other DDR and p53 pathway modulators.

bioRxiv · May 20, 2024 · PreprintCancer Biology