Ileana Lorenzini

This study shows ADAR2-mediated RNA editing promotes TDP-43 nuclear export and alters its RNA binding, contributing to neurodegenerative disease mechanisms.

This study examines C9orf72 ALS/FTD patient-derived iPSC-microglia mono-cultures, finding they form RNA foci, have reduced C9orf72 protein, and show endosomal-lysosomal dysfunction, but no significant microglial-enriched gene expression differences.

The paper shows that increased glycolysis is neuroprotective in ALS by improving locomotion and lifespan in Drosophila models through glucose transporter and PFK overexpression.