A Cdc42-Borg4-Septin 7 axis regulates HSCs polarity and function
Ravinder Kandi, Katharina Senger, Ani Grigoryan, Karin Soller, Vadim Sakk, Tanja Schuster, Karina Eiwen, Manoj B. Menon, Matthias Gaestel, Yi Zheng, Maria Carolina Florian, Hartmut Geiger
This study identifies a Cdc42-Borg4-Sep7 axis that regulates HSC polarity and function by controlling the polar distribution of these proteins and affecting engraftment potential and LMPP frequency.
EMBO Reports · Oct 18, 2021Peer-reviewedDevelopmental Biology