Weston R. Spivia

This study shows that D2-HG induces cachexia in mice by disrupting NAD+ homeostasis and autophagy, revealing metabolic vulnerabilities in skeletal muscle.

MitoPlex is a targeted MS assay for quantifying 37 mitochondrial proteins, paired with a metabolite assay, showing statin effects on mitochondrial function in different tissues.

The paper analyzes the proteomic architecture of human coronary and aortic atherosclerosis using mass spectrometry data from 200 specimens, identifying key protein networks and regulatory features associated with early disease.