Paul Sniegowski

This study shows diploids in Candida glabrata adapt differently to fluconazole than haploids, acquiring distinct mutations and aneuploidies, leading to higher fitness and MICs in some cases.

The paper evolves natural yeast isolates to select for cell separation, identifying AMN1 deactivation and Rim101 pathway mutations in haploids, and Hawthorne's deletion in diploids as key adaptations.

This study shows that mtDNA copy number in yeast cultures increases up to fourfold during growth, with variations depending on metabolic state and strain.