RBM10 loss induces aberrant splicing of cytoskeletal and extracellular matrix mRNAs and promotes metastatic fitness.
Gnana Prakasam Krishnamoorthy, Anthony Robert Glover, Brian R. Untch, Nickole Sigcha‐Coello, Bin Xu, Dina Vukel, Yi Liu, Vera Tiedje, Jose Mario Bello Pineda, Katherine Berman, Prasanna P. Tamarapu, Adrián Acuña-Ruíz, Mahesh Saqcena, Elisa de Stanchina, Laura Boucai, , James A. Fagin
This study shows that RBM10 loss causes aberrant splicing of cytoskeletal and ECM genes, leading to RAC1 activation and metastatic fitness in thyroid cancer.
The Journal of Experimental Medicine · Jan 14, 2025Peer-reviewedCancer Biology