Author

Dimitris Ttoouli

University of Duisburg-EssenORCID 0009-0008-7828-3051Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Bioinformatics· 2 Immunology· 1

Signature Assays, Organisms & Methods

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Research Focus:clustering· 3 Research Focus:cell type annotation· 2 Assay:scRNA-seq· 2 Approach:statistical model· 2 Research Focus:benchmarking· 1 Assay:CITE-seq· 1 Research Focus:differential expression· 1 Research Focus:dimensionality reduction· 1

Frequent Co-Authors

Daniel E. HoffmanniD· 2 shared Bettina BudeusiD· 1 shared Elena SiakaevaiD· 1 shared Farnoush FarahpouriD· 1 shared Johannes Andreas Korfhage· 1 shared Jun WangiD· 1 shared Mahamudul Hasan BhuyaniD· 1 shared Simo KitanovskiiD· 1 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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2 shared papersBioinformatics

Daniel E. HoffmannORCID

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3 papers

Recent·Most cited

CITE-seq of murine bone marrow plasmacytoid dendritic cells and haematopoietic progenitor cells in sepsis

Johannes Andreas Korfhage, Elena Siakaeva, Mahamudul Hasan Bhuyan, Bettina Budeus, Dimitris Ttoouli, Tobias Lautwein, Stefanie B. Flohé, Stefanie Scheu

The paper provides CITE-seq data of bone marrow cells from septic and sham mice to study transcriptional and surface marker changes in sepsis.

bioRxiv · Jul 21, 2026 · PreprintImmunology

Multiplets in scRNA-seq data: extent of the problem and efficacy of methods for removal

Dimitris Ttoouli, Daniel E. Hoffmann

This study evaluates multiplet rates in scRNA-seq data and shows that existing detection methods are insufficient, leading to distorted clustering and annotation.

PLoS ONE · Oct 30, 2025Peer-reviewedBioinformatics

scBubbletree: quantitative visualization of single cell RNA-seq data

Simo Kitanovski, Yingying Cao, Dimitris Ttoouli, Farnoush Farahpour, Jun Wang, Daniel E. Hoffmann

scBubbletree provides a scalable visualization method for scRNA-seq data by clustering cells into bubbles on dendrograms, enabling quantitative assessment and biological interpretation.

BMC Bioinformatics · Sep 13, 2024Peer-reviewedBioinformatics