Jean‐Louis Mergny

The paper identifies dehydration-responsive left-handed G-quadruplexes (drLHG4s) and expands the sequence space for their formation through mutational analysis and crystal structures.

The paper demonstrates the presence of G-quadruplex structures in human blood plasma through experimental validation using synthetic and native nucleic acid samples.

G4All is a curated database of experimentally validated G-quadruplex-forming DNA and RNA sequences with controls, enabling comparative analysis and predictive model development.

The paper investigates G-quadruplex formation from six G-overhang permutations in telomeres, revealing differences in stability and folding that affect DNA polymerase activity.

This study identifies the NS3 protease domain of Yellow Fever Virus as a high-affinity G4 binder, revealing its interaction mechanism and potential as an antiviral target.

This study identifies and validates G-quadruplex-forming sequences in archaea, demonstrating their presence and function in vivo and identifying potential resolving enzymes.

This study shows RHPS4, a G-quadruplex ligand, disrupts Plasmodium falciparum mitochondrial DNA and metabolism, offering a new antimalarial strategy by targeting mtDNA G4 structures.

This study identifies G-quadruplexes as promoter elements that exclude nucleosomes and facilitate RNA polymerase II pausing.

This study shows that lysosomal membrane permeabilization enhances the effectiveness of RNA Polymerase I inhibitors against cancer cells.

This study identifies G-quadruplexes as key regulatory elements in human cis-regulatory elements, showing their association with chromatin states and cancer.