G4All is a curated database of experimentally validated G-quadruplex-forming DNA and RNA sequences with controls, enabling comparative analysis and predictive model development.

bioRxiv · Aug 6, 2026 · PreprintBiochemistry

Archaeal G-Quadruplexes: A Novel Model for Understanding Unusual DNA/RNA Structures Across the Tree of Life

Zackie Aktary, Kate Sorg, Anne Cucchiarini, Guglielmo Vesco, Dorian Noury, Rongxin Zhang, Thomas Jourdain, Daniela Verga, Pierre Mahou, Nicolas Olivier, Natália Bohálová, Otília Porubiaková, Václav Brázda, Marie Bouvier, Marta Kwapisz, , Lionel Guittat

This study identifies and validates G-quadruplex-forming sequences in archaea, demonstrating their presence and function in vivo and identifying potential resolving enzymes.

Nucleic Acids Research · Jan 21, 2026Peer-reviewedMolecular Biology

Lysosomal membrane permeabilization enhances the anticancer effects of RNA Polymerase I transcription inhibitors

Lucille Ferret, Jonathan G. Pol, Allan Sauvat, Gautier Stoll, Karla Alvarez-Valadez, Alexandra Müller, Julie Le Naour, F. Peyre, Gerasimos Anagnostopoulos, Isabelle Martins, Maria Chiara Maiuri, Harald Wodrich, Lionel Guittat, Jean‐Louis Mergny, Guido Kroemer, Mojgan Djavaheri‐Mergny

This study shows that lysosomal membrane permeabilization enhances the effectiveness of RNA Polymerase I inhibitors against cancer cells.

Autophagy · Jun 18, 2025Peer-reviewedCancer Biology