Fadil A. Bidmos

Antibiotic treatment of meningococcal and other sepsis causative bacteria triggers the release of histone-like proteins (HLPs) that damage the endothelium and drive coagulopathy, but these effects can be neutralized by non-anticoagulant heparins or anti-HLP antibodies.

The paper validates a general-purpose biology-trained AI model for predicting antibody antigen targets using only amino acid sequences, achieving correct predictions in three out of ten tests.