Edwin Alexander Yates

This paper investigates why aryl sulfatases are inhibited by sulfamate warheads while carbohydrate sulfatases are not, using structural and computational analyses.

Antibiotic treatment of meningococcal and other sepsis causative bacteria triggers the release of histone-like proteins (HLPs) that damage the endothelium and drive coagulopathy, but these effects can be neutralized by non-anticoagulant heparins or anti-HLP antibodies.

This study investigates the role of Akkermansia muciniphila sulfatases in colonic mucin utilization, revealing unique adaptations compared to Bacteroides species.

The paper shows arylsulfamates inhibit Bacteroides growth on sulfated glycans via a lipid kinase, not carbohydrate sulfatases, and identifies resistance mechanisms.

This study examines how FGF-4 concentration and time affect phosphorylation of FRS2, MAPK1, and MAPK3 in Rama 27 fibroblasts, revealing oscillatory and bell-shaped responses at different concentrations.

This study shows that Omicron SARS-CoV-2 spike proteins balance heparan sulfate interaction stability and dynamics to enhance mobility in the extracellular matrix, which can be targeted pharmacologically.

This study characterizes a Bacteroides eggerthii lyase that efficiently cleaves heparin to release a rare anticoagulant disaccharide, offering improved methods for quality control.