Author

Cheng‐Hock Toh

Royal Liverpool University HospitalORCID 0000-0002-9708-8883Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Bioinformatics· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Assay:proteomics· 1 Approach:statistical model· 1 Research Focus:variant calling· 1 Assay:whole-genome sequencing· 1

Frequent Co-Authors

Aarnoud P. HuissooniD· 1 shared Abigail Furnell· 1 shared Adam J. MeadiD· 1 shared Adam P. LevineiD· 1 shared Adnan Yousaf Manzur· 1 shared Adrian James ThrasheriD· 1 shared Alan J. Greenhalgh· 1 shared Alasdair P. J. ParkeriD· 1 shared

Activity by Year

2018-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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1 shared paperBioinformatics

Aarnoud P. HuissoonORCID

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2 papers

Recent·Most cited

Bacterial histone-like proteins released during antibiotic treatment mediate vascular injury in meningococcal sepsis.

Dagmara McGuinness, Carla Johnson, Leandro Lemgruber, Fadil A. Bidmos, Edwin Alexander Yates, Jeremy E. Turnbull, Tom J. Evans, Rebecca E. McHugh, Andrew J. Roe, Gill R. Douce, Andrew J. Smith, Roisin Ure, Cheng‐Hock Toh, Simon Timothy Abrams, Jethro Adam Herberg, , Christopher A. Moxon

Antibiotic treatment of meningococcal and other sepsis causative bacteria triggers the release of histone-like proteins (HLPs) that damage the endothelium and drive coagulopathy, but these effects can be neutralized by non-anticoagulant heparins or anti-HLP antibodies.

bioRxiv · Jul 16, 2026 · PreprintMicrobiology

Telomerecat: A Ploidy-Agnostic Method For Estimating Telomere Length From Whole Genome Sequencing Data

James H. R. Farmery, Mike L. Smith, NIHR BioResource - Rare Diseases, Aarnoud P. Huissoon, Abigail Furnell, Adam J. Mead, Adam P. Levine, Adnan Yousaf Manzur, Adrian James Thrasher, Alan J. Greenhalgh, Alasdair P. J. Parker, Alba Sanchis‐Juan, Alex Richter, Alice Gardham, Allan Lawrie, , Emma L. Wakeling

Telomerecat estimates telomere length from whole-genome sequencing data without requiring prior knowledge of ploidy, showing good performance and detecting expected patterns in various data types.

Scientific Reports · Jan 16, 2018Peer-reviewedBioinformatics