Helen M. Belálcazar

This study shows that KDM5 is required in specific Drosophila brain cells for proper mushroom body formation and cognitive function, with Pros acting downstream of KDM5 to regulate neurodevelopment.

This study shows that KDM5 is essential for synaptic structure and function at the Drosophila neuromuscular junction through both demethylase-dependent and independent mechanisms.

This study shows that the SK3 channel agonist 1-EBIO has age-dependent neuroprotective effects against AMPA excitotoxicity in dopaminergic neurons in organotypic cultures.

This study identifies KDM5 as a critical regulator of prothoracic gland function in Drosophila by promoting endoreplication and ecdysone biosynthesis.

This study shows that KDM5 is essential for larval development in Drosophila, with loss of function causing developmental delay and cell death, independent of known demethylase and chromatin binding activities.