Julie Secombe

This study shows that KDM5's non-enzymatic activities, not just demethylation, are critical for proper genomic organization and neuronal function in the brain.

This study identifies KDM5's role in regulating mitochondrial gene expression in Drosophila prothoracic gland cells, showing its necessity for viability and highlighting its potential involvement in related disorders.

This study investigates the role of retrotransposon expression and insertions in aging using Drosophila, finding that expression, not insertion, is linked to longevity.

The paper uses proximity labeling to identify KDM5 interactors in Drosophila, revealing novel chromatin remodeling and regulatory complex associations.

This study shows that KDM5 is required in specific Drosophila brain cells for proper mushroom body formation and cognitive function, with Pros acting downstream of KDM5 to regulate neurodevelopment.

This study shows that KDM5 is essential for synaptic structure and function at the Drosophila neuromuscular junction through both demethylase-dependent and independent mechanisms.

This study identifies KDM5 as a critical regulator of prothoracic gland function in Drosophila by promoting endoreplication and ecdysone biosynthesis.

This study shows that KDM5 is essential for larval development in Drosophila, with loss of function causing developmental delay and cell death, independent of known demethylase and chromatin binding activities.