Robert K. Prud’homme

This paper introduces a post-loading method for mRNA into lipid nanoparticles to reduce cold storage requirements, achieving comparable delivery efficiency to conventional methods.

This study shows that DSPE-PEG fails to retain mAbs on LNPs in vivo, while a higher molecular weight PCL-b-PEG anchor maintains stability, highlighting the importance of anchoring strength for extrahepatic delivery.

The paper develops MECS NPs with controlled surface charge to enhance mucus transport and cell binding for improved mucosal drug delivery.