Brian K. Wilson

DSPE-PEG does not retain targeting antibodies on LNP surfaces in vivo; a higher molecular weight anchor is required

This study shows that DSPE-PEG fails to retain mAbs on LNPs in vivo, while a higher molecular weight PCL-b-PEG anchor maintains stability, highlighting the importance of anchoring strength for extrahepatic delivery.

Liquid crystalline mesophase spacing as a quantitative predictor of release kinetics for co-loaded hydrophilic and hydrophobic payloads

This paper shows that mesophase spacing in liquid crystalline nanocarriers predicts hydrophilic payload release kinetics, linking material composition to functional performance.

RNA post hoc loading into empty lipid nanoparticles occurs on millisecond timescales during turbulent mixing

The paper investigates RNA post hoc loading into empty lipid nanoparticles using turbulent mixing and finds it occurs within 12 ms under optimal conditions.

A Strategic Blend of Stabilizing Polymers to Control Particle Surface Charge for Enhanced Mucus Transport and Cell Binding

The paper develops MECS NPs with controlled surface charge to enhance mucus transport and cell binding for improved mucosal drug delivery.