Leah B. Zamechek

This paper identifies a microbiota-driven neuroepithelial circuit that promotes GEJ tumorigenesis through bile acid remodeling and bacterial metabolites.

The paper shows that gastrin loss activates a vagal reflex that promotes CCK2R+ stem cell expansion and preneoplasia in gastric inflammation.

This paper shows that sensory neurons form long-term inflammatory memory, enhancing gastric regeneration and tumor susceptibility after injury.

This study identifies Tff2+ progenitors in the gastric corpus as the primary source of SPEM and gastric cancer following injury, showing they can bypass metaplasia and progress directly to dysplasia.

This study identifies NTN1/NEO1 as a key driver of pancreatic tumorigenesis and metastasis by promoting cancer stemness, EMT, and nerve innervation.

This paper shows that a CXCR4 partial agonist enhances immunotherapy in gastric cancer by targeting PMN-MDSCs and granulopoiesis.

This study challenges the traditional model of intestinal stem cells by showing that Lgr5+ cells are not the sole stem cell compartment and that stemness exists in the isthmus region, contributing to homeostasis and regeneration.